Zscan4 binds nucleosomal microsatellite DNA and protects mouse two-cell embryos from DNA damage

Authors: Rajini Srinivasan, Nataliya Nady, Neha Arora, Laura J. Hsieh, Tomek Swigut, Geeta J. Narlikar, Mark Wossidlo, Joanna Wysocka

Published: 2020-03-20

DOI: 10.1126/sciadv.aaz9115

Source: Full article

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Abstract

A developmentally regulated mechanism, mediated by a zinc finger protein Zscan4, protects genome integrity in early embryos.