Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing

Authors: Natascha Sommer, Nasim Alebrahimdehkordi, Oleg Pak, Fenja Knoepp, Ievgen Strielkov, Susan Scheibe, Eric Dufour, Ana Andjelković, Akylbek Sydykov, Alireza Saraji, Aleksandar Petrovic, Karin Quanz, Matthias Hecker, Manish Kumar, Joel Wahl, Simone Kraut, Werner Seeger, Ralph T. Schermuly, Hossein A. Ghofrani, Kerstin Ramser, Thomas Braun, Howard T. Jacobs, Norbert Weissmann, Marten Szibor

Published: 2020-04-15

DOI: 10.1126/sciadv.aba0694

Source: Full article

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Abstract

Signaling from the mitochondrial respiratory chain is essential for acute vascular oxygen sensing in the lung.