Intracellular delivery of Parkin rescues neurons from accumulation of damaged mitochondria and pathological α-synuclein

Authors: Eunna Chung, Youngsil Choi, Jiae Park, Wonheum Nah, Jaehyung Park, Yukdong Jung, Joonno Lee, Hyunji Lee, Soyoung Park, Sunyoung Hwang, Seongcheol Kim, Jongseok Lee, Dongjae Min, Junghwan Jo, Shinyoung Kang, Minyong Jung, Phil Hyu Lee, H. Earl Ruley, Daewoong Jo

Published: 2020-04-29

DOI: 10.1126/sciadv.aba1193

Source: Full article

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Abstract

Cell-permeable Parkin ameliorates Parkinson’s disease-like phenotypes induced by mitochondrial poisons and aggregated α-synuclein.