Glutathione dynamics determine the therapeutic efficacy of mesenchymal stem cells for graft-versus-host disease via CREB1-NRF2 pathway

Authors: Jisun Lim, Jinbeom Heo, Hyein Ju, Ji-Woong Shin, YongHwan Kim, Seungun Lee, Hwan Yeul Yu, Chae-Min Ryu, HongDuck Yun, Sujin Song, Ki-Sung Hong, Hyung-Min Chung, Hwa-Ryeon Kim, Jae-Seok Roe, Kihang Choi, In-Gyu Kim, Eui Man Jeong, Dong-Myung Shin

Published: 2020-05-20

DOI: 10.1126/sciadv.aba1334

Source: Full article

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Abstract

Real-time monitoring of GSH dynamics demonstrates the functional roles of CREB1-NRF2 pathway in MSC therapeutic potency.