Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor

Authors: Dan Yue, Zhujun Chen, Fanli Yang, Fei Ye, Sheng Lin, Bin He, Yanwei Cheng, Jichao Wang, Zimin Chen, Xi Lin, Jing Yang, Hua Chen, Zhonglin Zhang, Yu You, Honglu Sun, Ao Wen, Lingling Wang, Yue Zheng, Yu Cao, Yuhua Li, Guangwen Lu

Published: 2020-05-13

DOI: 10.1126/sciadv.aba5147

Source: Full article

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Abstract

BHV-1 gD structures reveal that viral ligand has a unique G-strand/α2-helix interloop interfering with nectin-1 binding.