Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome

Authors: Patrick K. McCamphill, Laura J. Stoppel, Rebecca K. Senter, Michael C. Lewis, Arnold J. Heynen, David C. Stoppel, Vinay Sridhar, Katie A. Collins, Xi Shi, Jen Q. Pan, Jon Madison, Jeffrey R. Cottrell, Kimberly M. Huber, Edward M. Scolnick, Edward B. Holson, Florence F. Wagner, Mark F. Bear

Published: 2020-05-20

DOI: 10.1126/scitranslmed.aam8572

Source: Full article

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Abstract

Selective inhibition of GSK3α corrects diverse impairments in theFmr1−/ymouse model of fragile X syndrome.