Targeting pancreatic islet PTP1B improves islet graft revascularization and transplant outcomes

Authors: Hugo Figueiredo, Ana Lucia C. Figueroa, Ainhoa Garcia, Rebeca Fernandez-Ruiz, Christophe Broca, Anne Wojtusciszyn, Rita Malpique, Rosa Gasa, Ramon Gomis

Published: 2019-06-19

DOI: 10.1126/scitranslmed.aar6294

Source: Full article

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Abstract

Inhibition of tyrosine phosphatase PTP1B in mouse and human islets promotes islet revascularization and improves graft survival and function.