A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body–like pathology

Authors: Juan A. Gerez, Natalia C. Prymaczok, Edward Rockenstein, Uli S. Herrmann, Petra Schwarz, Anthony Adame, Radoslav I. Enchev, Thibault Courtheoux, Paul J. Boersema, Roland Riek, Matthias Peter, Adriano Aguzzi, Eliezer Masliah, Paola Picotti

Published: 2019-06-05

DOI: 10.1126/scitranslmed.aau6722

Source: Full article

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Abstract

An iron-regulated ubiquitin ligase targets exogenous α-synuclein for degradation and counteracts Lewy body–like pathology in preclinical models.