Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection

Authors: Louise Leyre, Eugène Kroon, Claire Vandergeeten, Carlo Sacdalan, Donn J. Colby, Supranee Buranapraditkun, Alexandra Schuetz, Nitiya Chomchey, Mark de Souza, Wendy Bakeman, Rémi Fromentin, Suteeraporn Pinyakorn, Siriwat Akapirat, Rapee Trichavaroj, Suthat Chottanapund, Sopark Manasnayakorn, Rungsun Rerknimitr, Phandee Wattanaboonyoungcharoen, Jerome H. Kim, Sodsai Tovanabutra, Timothy W. Schacker, Robert O’Connell, Victor G. Valcour, Praphan Phanuphak, Merlin L. Robb, Nelson Michael, Lydie Trautmann, Nittaya Phanuphak, Jintanat Ananworanich, Nicolas Chomont,

Published: 2020-03-05

DOI: 10.1126/scitranslmed.aav3491

Source: Full article

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Abstract

Although a large pool of cells is infected during acute HIV infection, most of these early targets are rapidly cleared upon ART initiation.