Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease

Authors: Michael Ewers, Nicolai Franzmeier, Marc Suárez-Calvet, Estrella Morenas-Rodriguez, Miguel Angel Araque Caballero, Gernot Kleinberger, Laura Piccio, Carlos Cruchaga, Yuetiva Deming, Martin Dichgans, John Q. Trojanowski, Leslie M. Shaw, Michael W. Weiner, Christian Haass,

Published: 2019-08-28

DOI: 10.1126/scitranslmed.aav6221

Source: Full article

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Abstract

Higher CSF sTREM2 concentrations are associated with slower rates of cognitive decline in subjects with Alzheimer’s disease.