MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21

Authors: Anna E. Vilgelm, Nabil Saleh, Rebecca Shattuck-Brandt, Kelsie Riemenschneider, Lauren Slesur, Sheau-Chiann Chen, C. Andrew Johnson, Jinming Yang, Ashlyn Blevins, Chi Yan, Douglas B. Johnson, Rami N. Al-Rohil, Ensar Halilovic, Rondi M. Kauffmann, Mark Kelley, Gregory D. Ayers, Ann Richmond

Published: 2019-08-14

DOI: 10.1126/scitranslmed.aav7171

Source: Full article

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Abstract

CDK4/6 inhibition becomes effective in preclinical models of melanoma when combined with MDM2 antagonism.