Long-gap peripheral nerve repair through sustained release of a neurotrophic factor in nonhuman primates

Authors: Neil B. Fadia, Jacqueline M. Bliley, Gabriella A. DiBernardo, Donald J. Crammond, Benjamin K. Schilling, Wesley N. Sivak, Alexander M. Spiess, Kia M. Washington, Matthias Waldner, Han-Tsung Liao, Isaac B. James, Danielle M. Minteer, Casey Tompkins-Rhoades, Adam R. Cottrill, Deok-Yeol Kim, Riccardo Schweizer, Debra A. Bourne, George E. Panagis, M. Asher Schusterman, Francesco M. Egro, Insiyah K. Campwala, Tyler Simpson, Douglas J. Weber, Trent Gause, Jack E. Brooker, Tvisha Josyula, Astrid A. Guevara, Alexander J. Repko, Christopher M. Mahoney, Kacey G. Marra

Published: 2020-01-23

DOI: 10.1126/scitranslmed.aav7753

Source: Full article


Abstract

A polycaprolactone conduit containing growth factor–encapsulated microspheres repairs 5-cm median nerve defects in rhesus macaques.