Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel

Authors: Kaice A. LaFavers, Etienne Macedo, Pranav S. Garimella, Camila Lima, Shehnaz Khan, Jered Myslinski, Jeanette McClintick, Frank A. Witzmann, Seth Winfree, Carrie L. Phillips, Takashi Hato, Pierre C. Dagher, Xue-Ru Wu, Tarek M. El-Achkar, Radmila Micanovic

Published: 2019-10-02

DOI: 10.1126/scitranslmed.aaw3639

Source: Full article

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Abstract

Uromodulin inhibits systemic oxidative stress via TRPM2.