A vaccine-induced gene expression signature correlates with protection against SIV and HIV in multiple trials

Authors: Philip K. Ehrenberg, Shida Shangguan, Biju Issac, Galit Alter, Aviva Geretz, Taisuke Izumi, Christopher Bryant, Michael A. Eller, Frank Wegmann, Richard Apps, Matthew Creegan, Diane L. Bolton, Rafick P. Sekaly, Merlin L. Robb, Robert A. Gramzinski, Maria G. Pau, Hanneke Schuitemaker, Dan H. Barouch, Nelson L. Michael, Rasmi Thomas

Published: 2019-08-28

DOI: 10.1126/scitranslmed.aaw4236

Source: Full article

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Abstract

A gene signature in B cells associates with protective efficacy of different vaccine regimens against SIV and HIV infection.