The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation

Authors: Melissa-Rose Abrahams, Sarah B. Joseph, Nigel Garrett, Lynn Tyers, Matthew Moeser, Nancie Archin, Olivia D. Council, David Matten, Shuntai Zhou, Deelan Doolabh, Colin Anthony, Nilu Goonetilleke, Salim Abdool Karim, David M. Margolis, Sergei Kosakovsky Pond, Carolyn Williamson, Ronald Swanstrom

Published: 2019-10-09

DOI: 10.1126/scitranslmed.aaw5589

Source: Full article

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Abstract

Outgrowth virus phylogeny suggests that most of the long-lived, replication-competent HIV-1 reservoir is formed near the time of therapy initiation.