Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases

Authors: Lingxin Zhu, Yi Tang, Xiao-Yan Li, Evan T. Keller, Jingwen Yang, Jung-Sun Cho, Tamar Y. Feinberg, Stephen J. Weiss

Published: 2020-02-06

DOI: 10.1126/scitranslmed.aaw6143

Source: Full article

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Abstract

Independent of cathepsin K, the osteoclast-derived matrix metalloproteinases MMP9 and MMP14 codependently drive bone resorption.