A dual apolipoprotein C-II mimetic–apolipoprotein C-III antagonist peptide lowers plasma triglycerides

Authors: Anna Wolska, Larry Lo, Denis O. Sviridov, Mohsen Pourmousa, Milton Pryor, Soumitra S. Ghosh, Rahul Kakkar, Michael Davidson, Sierra Wilson, Richard W. Pastor, Ira J. Goldberg, Debapriya Basu, Steven K. Drake, Antony Cougnoux, Ming Jing Wu, Saskia B. Neher, Lita A. Freeman, Jingrong Tang, Marcelo Amar, Matt Devalaraja, Alan T. Remaley

Published: 2020-01-30

DOI: 10.1126/scitranslmed.aaw7905

Source: Full article

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Abstract

An apolipoprotein C-II peptide mimetic for the treatment of hypertriglyceridemia activates lipoprotein lipase and blocks apolipoprotein C-III.