Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors

Authors: Johanna M. Schafer, Brian D. Lehmann, Paula I. Gonzalez-Ericsson, Clayton B. Marshall, J. Scott Beeler, Lindsay N. Redman, Hailing Jin, Violeta Sanchez, Matthew C. Stubbs, Peggy Scherle, Kimberly N. Johnson, Quanhu Sheng, Joseph T. Roland, Joshua A. Bauer, Yu Shyr, Bapsi Chakravarthy, Bret C. Mobley, Scott W. Hiebert, Justin M. Balko, Melinda E. Sanders, Phillip C. C. Liu, Jennifer A. Pietenpol

Published: 2020-03-11

DOI: 10.1126/scitranslmed.aaw8275

Source: Full article


Abstract

This study demonstrates the potential utility of BET and MEK inhibitors for advanced MYCN-expressing triple-negative breast cancer.