PD-1H (VISTA)–mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus

Authors: Xue Han, Matthew D. Vesely, Wendy Yang, Miguel F. Sanmamed, Ti Badri, Jude Alawa, Francesc López-Giráldez, Patricia Gaule, Sang Won Lee, Jian-Ping Zhang, Xinxin Nie, Ala Nassar, Agedi Boto, Dallas B. Flies, Linghua Zheng, Tae Kon Kim, Gilbert W. Moeckel, Jennifer M. McNiff, Lieping Chen

Published: 2019-12-12

DOI: 10.1126/scitranslmed.aax1159

Source: Full article

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Abstract

PD-1H (VISTA) is immunosuppressive during lupus progression and could be targeted by an agonistic antibody for therapy.