Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response

Authors: David Sharon, Severine Cathelin, Sara Mirali, Justin M. Di Trani, David J. Yanofsky, Kristine A. Keon, John L. Rubinstein, Aaron D. Schimmer, Troy Ketela, Steven M. Chan

Published: 2019-10-30

DOI: 10.1126/scitranslmed.aax2863

Source: Full article

---

Abstract

Tedizolid, an oxazolidinone-class antibiotic, overcomes resistance to venetoclax in AML.