Reproducing human and cross-species drug toxicities using a Liver-Chip

Authors: Kyung-Jin Jang, Monicah A. Otieno, Janey Ronxhi, Heng-Keang Lim, Lorna Ewart, Konstantia R. Kodella, Debora B. Petropolis, Gauri Kulkarni, Jonathan E. Rubins, David Conegliano, Janna Nawroth, Damir Simic, Wing Lam, Monica Singer, Erio Barale, Bhanu Singh, Manisha Sonee, Anthony J. Streeter, Carl Manthey, Barry Jones, Abhishek Srivastava, Linda C. Andersson, Dominic Williams, Hyoungshin Park, Riccardo Barrile, Josiah Sliz, Anna Herland, Suzzette Haney, Katia Karalis, Donald E. Ingber, Geraldine A. Hamilton

Published: 2019-11-07

DOI: 10.1126/scitranslmed.aax5516

Source: Full article


Abstract

A rat, dog, and human Liver-Chip designed using microengineered Organs-on-Chips technology recapitulates species-specific drug toxicities.