CD3 bispecific antibody–induced cytokine release is dispensable for cytotoxic T cell activity

Authors: Ji Li, Robert Piskol, Ryan Ybarra, Ying-Jiun J. Chen, Jason Li, Dionysos Slaga, Maria Hristopoulos, Robyn Clark, Zora Modrusan, Klara Totpal, Melissa R. Junttila, Teemu T. Junttila

Published: 2019-09-04

DOI: 10.1126/scitranslmed.aax8861

Source: Full article

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Abstract

Cytokine release induced by anti-HER2/CD3 is mediated by TNF-α and can be suppressed by blocking TNF-α, IL-6, or IL-1 without affecting efficacy.