A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure

Authors: Michelle L. Cook Sangar, Emily J. Girard, Gene Hopping, Chunfeng Yin, Fiona Pakiam, Mi-Youn Brusniak, Elizabeth Nguyen, Raymond Ruff, Mesfin M. Gewe, Kelly Byrnes-Blake, Natalie W. Nairn, Dennis M. Miller, Christopher Mehlin, Andrew D. Strand, Andrew J. Mhyre, Colin E. Correnti, Roland K. Strong, Julian A. Simon, James M. Olson

Published: 2020-03-05

DOI: 10.1126/scitranslmed.aay1041

Source: Full article


Abstract

A scorpion-derived peptide-steroid conjugate accumulates in cartilage and reverses inflammation in a rat model of arthritis without steroid toxicity.