Cerebellar oscillations driven by synaptic pruning deficits of cerebellar climbing fibers contribute to tremor pathophysiology

Authors: Ming-Kai Pan, Yong-Shi Li, Shi-Bing Wong, Chun-Lun Ni, Yi-Mei Wang, Wen-Chuan Liu, Liang-Yin Lu, Jye-Chang Lee, Etty P. Cortes, Jean-Paul G. Vonsattel, Qian Sun, Elan D. Louis, Phyllis L. Faust, Sheng-Han Kuo

Published: 2020-01-16

DOI: 10.1126/scitranslmed.aay1769

Source: Full article

---

Abstract

Excessive cerebellar oscillations, resulting from GluRδ2-dependent pruning deficits of climbing fiber–to–Purkinje cell synapses, drive tremor.