β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade

Authors: Fang Zhang, Mary Gannon, Yunjia Chen, Shun Yan, Sixue Zhang, Wendy Feng, Jiahui Tao, Bingdong Sha, Zhenghui Liu, Takashi Saito, Takaomi Saido, C. Dirk Keene, Kai Jiao, Erik D. Roberson, Huaxi Xu, Qin Wang

Published: 2020-01-16

DOI: 10.1126/scitranslmed.aay6931

Source: Full article

---

Abstract

Noradrenergic signaling sensitizes pathological GSK3β/tau activation to nanomolar Aβ.