Wnt-mediated endothelial transformation into mesenchymal stem cell–like cells induces chemoresistance in glioblastoma

Authors: Menggui Huang, Duo Zhang, Janet Y. Wu, Kun Xing, Eujin Yeo, Chunsheng Li, Lin Zhang, Eric Holland, Lutian Yao, Ling Qin, Zev A. Binder, Donald M. O’Rourke, Steven Brem, Constantinos Koumenis, Yanqing Gong, Yi Fan

Published: 2020-02-27

DOI: 10.1126/scitranslmed.aay7522

Source: Full article

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Abstract

Glioblastoma-associated endothelial cells transform into mesenchymal stem cell–like cells via Wnt/β-catenin, inducing tumor resistance to chemotherapy.