Identification of tetranectin-targeting monoclonal antibodies to treat potentially lethal sepsis

Authors: Weiqiang Chen, Xiaoling Qiang, Yongjun Wang, Shu Zhu, Jianhua Li, Ariella Babaev, Huan Yang, Jonathan Gong, Lance Becker, Ping Wang, Kevin J. Tracey, Haichao Wang

Published: 2020-04-15

DOI: 10.1126/scitranslmed.aaz3833

Source: Full article

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Abstract

An antibody strategy prevents harmful TN/HMGB1 interaction and resultant macrophage pyroptosis and immunosuppression in sepsis.