Blocking immunosuppressive neutrophils deters pY696-EZH2–driven brain metastases

Authors: Lin Zhang, Jun Yao, Yongkun Wei, Zhifen Zhou, Ping Li, Jingkun Qu, Akosua Badu-Nkansah, Xiangliang Yuan, Yu-Wen Huang, Kazutaka Fukumura, Xizeng Mao, Wei-Chao Chang, Jodi Saunus, Sunil Lakhani, Jason T. Huse, Mien-Chie Hung, Dihua Yu

Published: 2020-05-27

DOI: 10.1126/scitranslmed.aaz5387

Source: Full article


Abstract

G-CSF antibodies and immune checkpoint blockade with Src inhibitors block neutrophil infiltration to impede pY696-EZH2–driven brain metastasis.