ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension

Authors: Lai-Ming Yung, Peiran Yang, Sachindra Joshi, Zachary M. Augur, Stephanie S. J. Kim, Geoffrey A. Bocobo, Teresa Dinter, Luca Troncone, Po-Sheng Chen, Megan E. McNeil, Mark Southwood, Sergio Poli de Frias, John Knopf, Ivan O. Rosas, Dianne Sako, R. Scott Pearsall, John D. Quisel, Gang Li, Ravindra Kumar, Paul B. Yu

Published: 2020-05-13

DOI: 10.1126/scitranslmed.aaz5660

Source: Full article


Abstract

ACTRIIA-Fc, an activin and GDF8/11 ligand trap, improves hemodynamics and exerts antiremodeling effects in experimental pulmonary hypertension.