Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis

Authors: Nurit P. Azouz, Andrea M. Klingler, Purnima Pathre, John A. Besse, Netali Ben Baruch-Morgenstern, Adina Y. Ballaban, Garrett A. Osswald, Michael Brusilovsky, Jeff E. Habel, Julie M. Caldwell, Mario A. Ynga-Durand, Pablo J. Abonia, Yueh-Chiang Hu, Ting Wen, Marc E. Rothenberg

Published: 2020-05-27

DOI: 10.1126/scitranslmed.aaz7773

Source: Full article

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Abstract

Eosinophilic esophagitis is mediated by uncontrolled proteolytic activity of kallikrein 5 influencing the epithelial barrier and innate immunity.