Authors: Yuxiang Wang, Yawen Ding, Dan Yao, Hong Dong, Changwei Ji, Jinhui Wu, Yiqiao Hu, Ahu Yuan
Published: 2021-02-01
Source: Full article
AbstractInsufficient T‐cell infiltration seriously hinders the efficacy of tumor immunotherapy. Induction of immunogenic cell death (ICD) is a potentially feasible approach to increase T‐cell infiltration. Since ionizing radiation can only induce low‐level ICD, this study constructs Cu‐based nanoscale coordination polymers (Cu‐NCPs) with mixed‐valence (Cu+/Cu2+), which can simultaneously and independently induce the generation of Cu+‐triggered hydroxyl radicals and Cu2+‐triggered GSH elimination, to synergize with radiation therapy for potent ICD induction. Markedly, this synergetic therapy remarkably enhances dendritic cell maturation and promotes antitumor CD8+ T‐cell infiltration, thereby potentiating the development of checkpoint blockade immunotherapies against primary and metastatic tumors.