Evolutionarily conserved sequence motif analysis guides development of chemically defined hydrogels for therapeutic vascularization

Authors: Jia Jia, Eun Je Jeon, Mei Li, Dylan J. Richards, Soojin Lee, Youngmee Jung, Ryan W. Barrs, Robert Coyle, Xiaoyang Li, James C. Chou, Michael J. Yost, Sharon Gerecht, Seung-Woo Cho, Ying Mei

Published: 2020-08-27

DOI: 10.1126/sciadv.aaz5894

Source: Full article

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Abstract

Motif analysis on evolutionarily conserved regions in laminin enabled the discovery of novel ligands for hydrogel development.