Cryo-EM structure of NPF-bound human Arp2/3 complex and activation mechanism

Authors: Austin Zimmet, Trevor Van Eeuwen, Malgorzata Boczkowska, Grzegorz Rebowski, Kenji Murakami, Roberto Dominguez

Published: 2020-06-05

DOI: 10.1126/sciadv.aaz7651

Source: Full article

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Abstract

A cryo-EM structure and functional study show that Arp2/3 complex activation requires NPF-mediated delivery of actin to both Arps.