Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability

Authors: Sumeet Nayak, Jennifer A. Calvo, Ke Cong, Min Peng, Emily Berthiaume, Jessica Jackson, Angela M. Zaino, Alessandro Vindigni, M. Kyle Hadden, Sharon B. Cantor

Published: 2020-06-10

DOI: 10.1126/sciadv.aaz7808

Source: Full article

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Abstract

Translesion synthesis is a cancer adaptation that suppresses replication stress–induced gaps that limit fitness.