Inhibition of neutral sphingomyelinase 2 promotes remyelination

Authors: Seung-Wan Yoo, Amit Agarwal, Matthew D. Smith, Saja S. Khuder, Emily G. Baxi, Ajit G. Thomas, Camilo Rojas, Mohammed Moniruzzaman, Barbara S. Slusher, Dwight E. Bergles, Peter A. Calabresi, Norman J. Haughey

Published: 2020-10-02

DOI: 10.1126/sciadv.aba5210

Source: Full article


Abstract

Targeting a sphingomyelin hydrolase improves the structure of remyelinated fibers in a mouse model of multiple sclerosis.