ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism

Authors: Rasmus Pihl, Rasmus K. Jensen, Emil C. Poulsen, Lisbeth Jensen, Annette G. Hansen, Ida B. Thøgersen, József Dobó, Péter Gál, Gregers R. Andersen, Jan J. Enghild, Steffen Thiel

Published: 2021-01-08

DOI: 10.1126/sciadv.aba7381

Source: Full article

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Abstract

ITIH4 forms complexes with proteases upon cleavage that inhibit proteolysis by a novel inhibitory mechanism.