A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells

Authors: José M. Dias, Zhanna Alekseenko, Ashwini Jeggari, Marcelo Boareto, Jannik Vollmer, Mariya Kozhevnikova, Hui Wang, Michael P. Matise, Andrey Alexeyenko, Dagmar Iber, Johan Ericson

Published: 2020-09-16

DOI: 10.1126/sciadv.aba8196

Source: Full article

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Abstract

A Shh/Gli-driven incoherent feed-forward loop circuit encodes time and counterbalances noise in temporal neural patterning.