A single molecular descriptor to predict solution behavior of therapeutic antibodies

Authors: Jonathan S. Kingsbury, Amandeep Saini, Sarah Marie Auclair, Li Fu, Michaela M. Lantz, Kevin T. Halloran, Cesar Calero-Rubio, Walter Schwenger, Christian Y. Airiau, Jifeng Zhang, Yatin R. Gokarn

Published: 2020-07-31

DOI: 10.1126/sciadv.abb0372

Source: Full article

---

Abstract

Colloidal interactions in dilute solution singularly enable selection of well-behaved antibodies during drug discovery.