Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson’s disease-linked

Authors: Noviana Wulansari, Wahyu Handoko Wibowo Darsono, Hye-Ji Woo, Mi-Yoon Chang, Jinil Kim, Eun-Jin Bae, Woong Sun, Ju-Hyun Lee, Il-Joo Cho, Hyogeun Shin, Seung-Jae Lee, Sang-Hun Lee

Published: 2021-02-17

DOI: 10.1126/sciadv.abb1540

Source: Full article

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Abstract

Human DNAJC6 Parkinson’s disease model reveals disruption of WNT-LMX1A regulatory loop during mDA neuron development.