Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease

Authors: Gabriella T. Heller, Francesco A. Aprile, Thomas C. T. Michaels, Ryan Limbocker, Michele Perni, Francesco Simone Ruggeri, Benedetta Mannini, Thomas Löhr, Massimiliano Bonomi, Carlo Camilloni, Alfonso De Simone, Isabella C. Felli, Roberta Pierattelli, Tuomas P. J. Knowles, Christopher M. Dobson, Michele Vendruscolo

Published: 2020-11-05

DOI: 10.1126/sciadv.abb5924

Source: Full article

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Abstract

A small molecule binds to a disordered protein in its monomeric form, preventing its aggregation linked to Alzheimer’s disease.