Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease

Authors: Xinwen Zhang, Rihua Wang, Di Hu, Xiaoyan Sun, Hisashi Fujioka, Kathleen Lundberg, Ernest R. Chan, Quanqiu Wang, Rong Xu, Margaret E. Flanagan, Andrew A. Pieper, Xin Qi

Published: 2020-12-05

DOI: 10.1126/sciadv.abb8680

Source: Full article

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Abstract

The Drp1-HK1-NLRP3 axis is a key mechanism of oligodendrocyte damage and white matter degeneration in AD.