Annexin-A1 SUMOylation regulates microglial polarization after cerebral ischemia by modulating IKKα stability via selective autophagy

Authors: Xing Li, Qian Xia, Meng Mao, Huijuan Zhou, Lu Zheng, Yi Wang, Zhen Zeng, Lulu Yan, Yin Zhao, Jing Shi

Published: 2021-01-20

DOI: 10.1126/sciadv.abc5539

Source: Full article

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Abstract

SUMOylation of annexin-A1 promotes an anti-inflammatory microglial phenotype and protects against cerebral ischemic injury.