Reengineering biocatalysts: Computational redesign of chondroitinase ABC improves efficacy and stability

Authors: Marian H. Hettiaratchi, Matthew J. O’Meara, Teresa R. O’Meara, Andrew J. Pickering, Nitzan Letko-Khait, Molly S. Shoichet

Published: 2020-08-19

DOI: 10.1126/sciadv.abc6378

Source: Full article

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Abstract

Computational redesign of chondroitinase ABC introduces 37 point mutations to improve enzyme stability and activity.