Macrophage activation on “phagocytic synapse” arrays: Spacing of nanoclustered ligands directs TLR1/2 signaling with an intrinsic limit

Authors: Miao Li, Haomin Wang, Wenqian Li, Xiaoji G. Xu, Yan Yu

Published: 2020-12-03

DOI: 10.1126/sciadv.abc8482

Source: Full article

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Abstract

The clustering of TLR1/2 acts as a driver in integrating the spatial cues of ligands into cell-level activation events.