1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer

Authors: Marisa K. Kilgour, Sarah MacPherson, Lauren G. Zacharias, Abigail E. Ellis, Ryan D. Sheldon, Elaine Y. Liu, Sarah Keyes, Brenna Pauly, Gillian Carleton, Bertrand Allard, Julian Smazynski, Kelsey S. Williams, Peter H. Watson, John Stagg, Brad H. Nelson, Ralph J. DeBerardinis, Russell G. Jones, Phineas T. Hamilton, Julian J. Lum

Published: 2021-01-20

DOI: 10.1126/sciadv.abe1174

Source: Full article

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Abstract

MNA contributes to the immune suppression of T cells and represents a potential immunotherapy target to treat human cancer.