Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression

Authors: Ke Zhang, Lisa Miorin, Tadashi Makio, Ishmael Dehghan, Shengyan Gao, Yihu Xie, Hualin Zhong, Matthew Esparza, Thomas Kehrer, Anil Kumar, Tom C. Hobman, Christopher Ptak, Boning Gao, John D. Minna, Zhijian Chen, Adolfo García-Sastre, Yi Ren, Richard W. Wozniak, Beatriz M.A. Fontoura

Published: 2021-02-09

DOI: 10.1126/sciadv.abe7386

Source: Full article

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Abstract

SARS-CoV-2 Nsp1 protein binds the mRNA export receptor NXF1-NXT1 to inhibit nuclear export of mRNAs and promote infection.