Anti-EGFR VHH-armed death receptor ligand–engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers

Authors: Yohei Kitamura, Nobuhiko Kanaya, Susana Moleirinho, Wanlu Du, Clemens Reinshagen, Nada Attia, Agnieszka Bronisz, Esther Revai Lechtich, Hikaru Sasaki, Joana Liliana Mora, Priscilla Kaliopi Brastianos, Jefferey L. Falcone, Aldebaran M. Hofer, Arnaldo Franco, Khalid Shah

Published: 2021-03-03

DOI: 10.1126/sciadv.abe8671

Source: Full article

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Abstract

This study presents a mechanism-based receptor-targeted cellular therapy approach to treat breast to brain metastasis.