BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation

Authors: Zlata Vershinin, Michal Feldman, Thilo Werner, Lital Estrella Weil, Margarita Kublanovsky, Elina Abaev-Schneiderman, Menachem Sklarz, Enid Y. N. Lam, Khawla Alasad, Sarah Picaud, Barak Rotblat, Ruth A. McAdam, Vered Chalifa-Caspi, Marcus Bantscheff, Trevor Chapman, Huw D. Lewis, Panagis Filippakopoulos, Mark A. Dawson, Paola Grandi, Rab K. Prinjha, Dan Levy

Published: 2021-05-26

DOI: 10.1126/sciadv.abf5374

Source: Full article

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Abstract

Lysine methylation of BRD4 selectively determines the recruitment of E2F1 to specific target genes to regulate mRNA translation.