Shared transcriptional profiles of atypical B cells suggest common drivers of expansion and function in malaria, HIV, and autoimmunity

Authors: Prasida Holla, Brian Dizon, Abhijit A. Ambegaonkar, Noga Rogel, Ella Goldschmidt, Arun K. Boddapati, Haewon Sohn, Dan Sturdevant, James W. Austin, Lela Kardava, Li Yuesheng, Poching Liu, Susan Moir, Susan K. Pierce, Asaf Madi

Published: 2021-05-26

DOI: 10.1126/sciadv.abg8384

Source: Full article

---

Abstract

Atypical B cells represent an IFN-γ–driven B cell lineage that may be similarly expanded in malaria, HIV, and autoimmunity.