Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis

Authors: Mireia Casulleras, Roger Flores-Costa, Marta Duran-Güell, José Alcaraz-Quiles, Silvia Sanz, Esther Titos, Cristina López-Vicario, Javier Fernández, Raquel Horrillo, Montserrat Costa, Pierre de la Grange, Richard Moreau, Vicente Arroyo, Joan Clària

Published: 2020-10-21

DOI: 10.1126/scitranslmed.aax5135

Source: Full article

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Abstract

Leukocyte endosomal trafficking plays a critical role in the anti-inflammatory actions of human albumin.